8X Anti-Dandruff Shampoo is indicated for the topical treatment of seborrhoeic dermatitis of the scalp in adults.
8x Shampoo contains Ciclopirox (1% w/v) + Zinc pyrithione (1% w/v)
Ciclopirox is a hydroxypyridone antifungal agent, although the relevance of this property for the indication of seborrhoeic dermatitis is not known. Ciclopirox acts by chelation of polyvalent cations (Fe3+ or Al3+), resulting in the inhibition of the metal-dependent enzymes that are responsible for the degradation of peroxides within the fungal cell. Zinc pyrithione is known to have both a non-specific keratolytic and antifungal activities. Thus it is effective in the treatment of seborrhoeic dermatitis and dandruff. Ciclopirox/zinc pyrithione combination has a synergistic effect on the growth control and the reduction of Malassezia population. Aloe vera acts as a natural conditioner.
Wet hair and apply approximately 1 teaspoon (5 mL) of 8X Shampoo onto the scalp. Up to 2 teaspoons (10 mL) may be used for long hair. Lather and leave on hair and scalp for 3 minutes. Avoid contact with eyes. Rinse off. Treatment should be repeated twice per week for 4 weeks, with a minimum of 3 days between applications.
If a patient with seborrhoeic dermatitis shows no clinical improvement after 4 weeks of treatment with 8X Shampoo, the diagnosis should be reviewed.
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